詹启敏
中国医学科学院肿瘤医院肿瘤研究所研究员，博士生导师，国家杰出青年基金获得者，教育部长江学者特聘教授，国家自然科学基金委创新研究群体首 席专家.
分子肿瘤学国家重点实验室主任，分子肿瘤学国家重点实验室第四届学术委员会委员.
联系方式：电话：010-67762694（办），010-87788421（实验室）
传真：010-67715058
E-mail：zhanqimin@pumc.edu.cn
研究方向
我们的研究工作主要定位在探讨细胞周期调控和肿瘤恶性表型形成的分子机制。重点研究p53, BRCA1, Gadd45, Aurora-A, cyclin B1 和 Nlp等重要细胞周期蛋白分子在细胞周期监测点、细胞中心体和基因组稳定性以及恶性肿瘤转移中的调控作用。同时，我们也关注非编码RNA在细胞DNA损伤反应和肿瘤转移中的生物学功能，采用基因组学的方法寻找人类食管癌发生发展的遗传变异，确定食管癌的分子标志物。
Research Description
The mainstream of research in Dr. Zhan’s group is to investigate the molecular mechanisms involved in the control of cell cycle progression and the development of tumor malignancy. The current studies are focused on the functions of some key cell cycle regulators, including p53, BRCA1, Gadd45, Aurora-A, cyclin B1 and Nlp in the control of cell cycle checkpoints, regulation of the maintenance of genomic stability and tumor metastasis. Major efforts are also made in the understanding on the roles of ncRNA in the cellular response to DNA damage and clinical tumor malignancy. In addition, genomic approaches are used to determine the genetic defects in the development of human esophageal squamous cell carcinomas (ESCC) and identify molecular biomarkers of ESCC in order to develop specific and efficient therapeutic approaches.
代表性论文:
1) Shao S, Liu R, Wang Y, Song Y, Zuo L, Xue L, Lu N, Hou N, Wang M, Yang X, Zhan Q*.Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice. J Clin Invest. 2010, 120(2):498-507.
2) Jin S, Gao H, Mazzacurati L, Wang Y, Fan W, Chen Q, Yu W, Wang M, Zhu X, Zhang C, Zhan Q*. BRCA1 Interaction of Centrosomal Protein Nlp Is Required for Successful Mitotic Progression. J Biol Chem. 2009, 284(34):22970-22977.
3) Song Y, Zhao C, Dong L, Fu M, Xue L, Huang Z, Tong T, Zhou Z, Chen A, Yang Z, Lu N and Zhan Q*. Overexpression of cyclin B1 in human esophageal quamous cell carcinoma cells induces tumor cell invasive growth and metastasis. Carcinogenesis. 2008, 29(2):307–315..
4) Ji J, Liu R, Tong T, Song Y, Wu M and Zhan Q*. Gadd45a Regulates Beta-catenin Distribution and Maintains Cell-cell Adhesion/contact Inhibition. Oncogene. 2007, 26(44):6396-6405.
5) Tong T, Ji J, Jin S, Li X, Fan W, Song Y, Wang MR, Liu ZH, Wu M and Zhan Q*. Gadd45a expression induces Bim dissociation from cytoskeleton and translocation to mitochondria. Mol Cell Biol. 2005, 25 (11):4488-4500.
语音报告：
细胞周期和肿瘤
