吴传跃
美国匹兹堡大学教授，教育部长江学者讲座教授，国家“千人计划”国家重点实验室平台引进人才，分子肿瘤学国家重点实验室特聘教授.
联系方式：
E-mail：carywu@pitt.edu
研究方向
课题组研究方向主要集中在细胞粘附， 迁移和生存的分子机制。具体研究课题包括：
1. 细胞微环境对肿瘤细胞粘附、迁移和转移的作用和分子机制
2. Integrin 信息传导和调控
3. Integrin-linked kinase, PINCH 和Parvin 蛋白质复合体结构和功能
4. Kindlin 和 migfilin 在细胞粘附， 迁移和生存的作用和分子机制
Research Description
Cell adhesion to extracellular matrix is a fundamental process that regulates cell migration, invasion, proliferation and survival. Alterations in cell-matrix adhesion and signaling are critically involved in the pathogenesis and progression of human cancer. The research in our laboratory focuses on the molecular mechanisms by which cells regulate cell-matrix adhesion and signal transduction. Students and post-doctoral researchers who enter our laboratory will learn a wide variety of molecular and cell biological techniques including molecular cloning, mutagenesis, gene transfer, protein expression, yeast two-hybrid and other protein-protein interaction assays, hybridoma production, cell culture, cell adhesion, cell migration, immunofluorescence microscopy, immunoprecipitation, Northern, Southern and Western blotting, cell proliferation, apoptosis, and immunohistochemistry, and will have opportunities of developing new research projects and contributing to the advance of this exciting area in molecular oncology.
代表性论文
1) Zhao, J., Zhang, Y., Ithychanda, S. S., Tu, Y., Chen, K., Qin, J. and Wu, C. Migfilin interacts with Src and contributes to cell-matrix adhesion- mediated survival signaling. J. Biol. Chem. 2009, 284(49):34308-34320.
2) Zhang, Y., Tu, Y., Zhao, J., Chen, K. and Wu, C. Reversion-Induced LIM (RIL) interaction with Src reveals a novel Src inactivation cycle. J. Cell Biol. 2009, 184(6):785-792.
3) Larjava, H., Plow, E. F. and Wu, C. Kindlins: Essential regulators of integrin signaling and cell-matrix adhesion. EMBO Reports. 2008, 9(12):1203-1208.
4) Vaynberg, J., Fukuda, T., Chen, K., Vinogradova, O., Velyvis, A., Tu, Y., Ng, L., Wu, C.* and Qin, J.* Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility. Mol. Cell. 2005, 17: 513-523.
5) Wu, C. PINCH, N(i)ck and the ILK: network wiring at cell-matrix adhesions. Trends in Cell Biology. 2005, 15(9):460-466.
