刘芝华
中国医学科学院肿瘤医院肿瘤研究所研究员，博士生导师，国家杰出青年基金获得者，教育部长江学者特聘教授.
分子肿瘤学国家重点实验室副主任.
联系方式：
电话：010-67723789（办），010-87788490（实验室）
传真：010-67723789
E-mail：liuzh@cicams.ac.cn
研究方向
本课题组主要研究方向为食管癌变的分子机理研究，用cDNA array方法寻找食管癌中差异表达基因，发现大批分化及炎症相关基因在食管癌中表达严重失调，其中S100家族成员在细胞分化及炎症反应中发挥重要作用，锌指转录因子KLF4 (Krüppel-like factor 4)在细胞增殖和分化中起重要作用，是胚胎干细胞自我更新和多能性所必须的。本课题组目前主要集中在这些基因的功能及调控网络的研究，包括S100家族成员及KLF4在肿瘤细胞分化调节及肿瘤侵袭转移中的作用及分子机制，转录调控及表观遗传学调控，在DNA损伤修复及放化疗敏感性中的作用等。长期目标是肿瘤分子标志物及分子靶标的发现。
Research Description
Research interests in Liu lab focus on the molecular mechanism of human esophageal squamous cell carcinoma (ESCC) initiation and progression. Currently, we are studying the cell differentiation regulation in ESCC. We found that many of the calcium-relevant and differentiation associated genes were down-regulated in ESCC by cDNA microarray. We are now studying the function and regulation network of the genes. The long term goal is to understand the role of these genes in ESCC and to develop new intervention strategies based on the understanding of differentiation regulation in ESCC, and find the biomarkers for early detection of cancers.
代表性论文
1) Tian Y, Luo A, Cai Y, Su Q, Ding F, Chen H, Liu Z*. MicroRNA-10b promotes human esophageal cancer cell migration and invasion through KLF4. J Biol Chem. 2010, 285(11):7986-7994.
2) Zhou Q, Hong Y, Zhan Q, Shen Y, Liu Z*: A role for Krüppel-like factor 4 in determining the outcome of p53 response to DNA damage. Cancer Res. 2009, 69(21):8284-8292.
3) Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao Z, Yang M, Liu J, Lin D*, Liu Z*: Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma. Cancer Res. 2009, 69(8):3451-3457.
4) Zhang L, Ding F, Cao W, Liu Z, Liu W, Yu Z, Wu Y, Li W, Li Y, Liu Z*: Antisense Stomatin-like protein 2 (SLP-2) showed decreased cell growth, tumorigenecity and cell adhesion in human esophageal squamous cell carcinoma. Clin Cancer Res. 2006, 12(5):1639-1646.
5) Li W, Ding F, Zhang L, Liu Z, Wu Y, Luo A, Wu M, Wang M, Zhan Q, Liu Z*: Overexpression of Stefin A in human esophageal squamous carcinoma cells inhibits tumor cell growth, angiogenesis, invasion and metastasis. Clin Cancer Res. 2005, 11(24):8753-8762.
