王明荣
中国医学科学院肿瘤医院肿瘤研究所研究员，博士生导师，国家杰出青年基金获得者.
分子肿瘤学国家重点实验室第四届学术委员会委员.
联系方式：
电话：010-87788788（办），010-87788425（实验室）
传真：010-87778651
E-mail：wangmr07@gmail.com
研究方向
1. 肿瘤相关基因的鉴定、功能及分子机理研究
应用遗传学、细胞生物学、分子生物学的最新技术，分析、鉴定恶性肿瘤发生、发展的关键基因。目前，我们发现了多个调节细胞增殖、凋亡（包括失巢凋亡）、粘附、运动、侵袭转移等表型的基因，正在进行生物学功能研究及其在细胞癌变、肿瘤演进中的作用机制研究。
2. 恶性肿瘤的分子标志研究
综合利用Oligo-array CGH、间期核M-FISH、cDNA microarray、蛋白质组学技术、组织芯片-免疫组化等技术，从染色体、基因及蛋白水平对常见恶性肿瘤的手术标本、活检组织、FOB、尿液及血液等进行分析，寻找与临床、病理相关的异常变化分子，探索可用于早期预警、早期诊断、预后判断及与靶向治疗的生物标志（谱）。
Research Description
Research interests in Wang’s lab focus on the identification of potential biomarkers for early detection, early diagnosis, prognosis, molecular classification as well as novel therapeutic targets. We are systematically detecting molecular aberrations at chromosomal, gene and protein levels by using the CGH, Oligo-array CGH, interphase M-FISH, cDNA microarray, proteomics and tissue array-IHC techniques. Our current research involves esophageal cancer, lung cancer, bladder cancer and colorectal cancer. Specimens analyzed include operative tissues, endoscope biopsy tissues, peripheral blood, urine and brush specimens by fiberoptic bronchoscope (FOB). We have found candidate genes which significantly regulate cell proliferation apoptosis (including anoikis), adhesion, migration and invasion. We are dissecting biological function of these candidate genes and the underlying mechanisms involved in carcinogenesis and cancer progression with the combination of genetics, cellular biology, and molecular biology techniques. The long term goal is to discover crucial genes and signaling pathways associated with the development and progression of common cancers, as well as develop novel therapeutic strategies for these malignant diseases.
代表性论文
1) Du X, Yang H, Liu S, Luo M, Hao J, Zhang Y, Lin D, Xu X, Cai Y, Zhan Q, Wang M*. Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinoma. Oncogene. 2009 Aug 17. [Epub ahead of print].
2) Feng Y, Lin D, Shi Z, Wang X, Shen X, Zhang Y, Du X, Luo M, Xu X, Han Y, Cai Y, Zhang Z, Zhan Q, Wang M*. Overexpression of PLK1 is associated with poor survival by inhibiting apoptosis via enhancement of survivin level in esophageal squamous cell carcinoma. Int J Cancer. 2009, 124(3):578-588.
3) Wang X, Wu Y, Ye B, Lin D, Feng Y, Zhang Z, Xu X, Han Y, Cai Y, Dong J, Zhan Q, Wu M, Wang M*. Suppression of Anoikis by SKP2 Amplification and Overexpression Promotes Metastasis of Esophageal Squamous Cell Carcinoma. Mol Cancer Res. 2009, 7(1):12-22.
4) Zhang Y, Feng Y, Shen X, Chen B, Du X, Luo M, Cai Y, Han Y, Xu X, Zhan Q, Wang M*. Exogenous expression of Esophagin/SPRR3 attenuates the tumorigenicity of esophageal squamous cell carcinoma cells via promoting apoptosis. Int J Cancer. 2008, 122(2):260-266.
5) Luo M, Shen X, Zhang Y, Wei F, Xu X, Cai Y, Zhang X, Sun Y, Zhan Q, Wu M, Wang M*. Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance. Cancer Res. 2006, 66(24):11690-11699.
