汪红英

中国医学科学院肿瘤医院肿瘤研究所研究员，博士生导师.

联系方式：

电话：010-877888665（实验室）
E-mail：hongyingwang@cicams.ac.cn

研究方向

慢性炎症与肿瘤的发生发展密切相关，不仅增加肿瘤的发生率而且能促进肿瘤的生长。肿瘤细胞主动地改变其微环境，以及炎性微环境对肿瘤细胞及组织干细胞功能的调节，都在肿瘤的发生发展中起着非常重要的作用。本课题组的科研方向集中在结肠炎促进结肠癌发生发展的机制研究。主要是从微环境的角度，研究炎症相关因子，如一氧化氮（nitric oxide，NO), 蛋白酶活化受体（proteinase activated receptors，PARs) 及Toll样受体（Toll like receptors，TLRs)等等，对肿瘤细胞的影响。用细胞分子生物学的方法研究细胞信号通路及炎症相关因子调节肿瘤细胞生长，凋亡，癌基因表达等行为的分子机制。由于Wnt/-catenin信号通路在调节胃肠组织干细胞功能，组织修复等方面的重要作用，本课题组的研究也集中在炎症对组织干细胞，Wnt/-catenin通路及组织纤维化等的调节。希望通过我们的研究，为预防、早诊、及治疗癌症提供新的思路和理论基础。

Research Description

Chronic inflammation, which is highly correlated with carcinogenesis, not only increases the incidence but also promote the growth of cancer. Interaction between inflammatory microenvironment and tumor cells plays critical roles in the initiation and progression of tumor. We are investigating colitis-related colonic tumorigenesis affected by inflammatory mediators, including nitric oxide (NO), proteinase activated receptors (PARs) and Toll like receptors (TLRs) et al. We focus on the cell signaling and molecular mechanism by which inflammatory mediators regulate the expression of oncogenes, induce apoptosis and proliferation. In addition, we are interested in the role of Wnt/beta-catenin pathway in the interaction of epithelial cells and microenvironment and the mechanisms by which inflammation affect stem cell and progenitor cell in gut. Finally, our goals are to find new strategies of early diagnosis, prevention, and treatment for colon cancer.

代表性论文

1) Wang H* and Cho CH. Effect of NF-kB signaling on apoptosis in chronic inflammation-associated carcinogenesis. Current Cancer Drug Target 2010, 10(6):593-599. * Co-corresponding author.
2)Wang H, Moreau F, Hirota C and MacNaughton W. Proteinase-activated receptors induce interleukin-8 expression by intestinal epithelial cells through ERK/RSK90 activation and histone acetylation. FASEB Journal. 2010, 24(6):1971-1980.
3) Wang H*, Zhang R, Wen S, McCafferty D, Beck P and MacNaughton W. Nitric oxide increases Wnt-induced secreted protein-1 (WISP-1/CCN4) expression and function in colitis. Journal of Molecular Medicine. 2009, 87(4):435-445. * Co-corresponding author.
4) Wang H, Wen S, Bunnett N, Leduc R, Hollenberg M and MacNaughton W. Proteinase-activated receptor 2 (PAR2) induces cyclooxygenase-2 expression through-catenin and CREB. Journal of Biological Chemistry. 2008, 283(2):809-815.
5) Wang H, MacNaughton W. Overexpressed -catenin blocks nitric oxide-induced apoptosis in colonic cancer cells. Cancer Research. 2005, 65(19):8604-8607.